The purpose of the study was to assess antidiabetic activity of ethanolic extract of Carica papaya Linn. Seeds (EECPS) in diabetic rats. Male wistar rats weighing (150-180 g) were divided into 5 groups of 5 animals each. Group I served as control, Group II was treated with alloxan monohydrate (120mg/kg, i.p.), Group III was treated with glibenclamide (0.1 mg/kg, p.o.). Groups IV and V received EECPS (100 mg/kg) and EECPS (300 mg/kg) respectively, for 21 days. Blood samples were analyzed for Blood glucose (BG) on day 0, 7, 14, 21, and 28 day. On day 28, blood samples were collected for the determination of serum insulin and glycosylated haemoglobin, High Density Lipoprotein, Low Density Lipoprotein, Triglyceride, Total protein and Cholesterol. Antioxidant studies were carried out for estimating the levels of Super oxide dismutase, reduced glutathione, Catalase and Lipid peroxidation. Results showed that EECPS significantly (P<0.05) lowered BG, Serum insulin, Cholesterol, Triglyceride, Low density lipoprotein, and significantly (P<0.05) increased levels of high density lipoprotein, total protein and glycosylated haemoglobin. It is concluded that EECPS is effective in lowering blood glucose and has antioxidant properties, thus suggesting its potential use as an antidiabetic agent.
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